2023 Publications

• Smith AM, Challagundla L, McGee IG, Warfield ZJ, Dos Santos E Santos C, Garrett MR, Grayson BE. Temporal shifts to the gut microbiome associated with cognitive dysfunction following high-fat diet consumption in a juvenile model of traumatic brain injury. Physiol Genomics. 2023 Dec 25. doi: 10.1152/physiolgenomics.00113.2023. Epub ahead of print. PMID: 38145288.
• Kalusche WJ, Case CT, Taylor EB. Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease. Clin Sci (Lond). 2023 Dec 14;137(23):1771-1785. doi: 10.1042/CS20230924. PMID: 38031726; PMCID: PMC10721433.
• Tang C, Zhang H, Border JJ, Liu Y, Fang X, Jefferson JR, Gregory A, Johnson C, Lee TJ, Bai S, Sharma A, Shin SM, Yu H, Roman RJ, Fan F. Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats. bioRxiv [Preprint]. 2023 Dec 6:2023.12.04.569939. doi: 10.1101/2023.12.04.569939. PMID: 38106132; PMCID: PMC10723354.
• Hirata T, Fan F, Fan L, Amin G, White T, Geurts AM, Kojima N, Takahashi T, Miyata N, Williams J, Roman RJ. Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-induced Nephropathy. J Cardiovasc Pharmacol. 2023 Dec 1;82(6):445-457. doi: 10.1097/FJC.0000000000001473. PMID: 37643020; PMCID: PMC10691661.
• Clemmer JS, Yen TE, Obi Y. Modeling the renoprotective mechanisms of SGLT2 inhibition in hypertensive chronic kidney disease. Physiol Rep. 2023 Nov;11(21):e15836. doi: 10.14814/phy2.15836. PMID: 37957121; PMCID: PMC10643202.
• Munusamy S, do Carmo JM, Hosler JP, Hall JE. Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin. Am J Physiol Renal Physiol. 2015 Oct 15;309(8):F731-43. doi: 10.1152/ajprenal.00188.2015. Epub 2015 Aug 19. PMID: 26290368; PMCID: PMC4609921.
• do Carmo JM, Dai X, Aitken N, Larson KM, Omoto ACM, Gulke RR, Wang Z, Li X, Mouton AJ, Hall JE, da Silva AA. Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents. Am J Physiol Regul Integr Comp Physiol. 2023 Oct 1;325(4):R401-R410. doi: 10.1152/ajpregu.00106.2023. Epub 2023 Jul 31. PMID: 37519251; PMCID: PMC10639017.
• Williamson A, da Silva A, do Carmo JM, Le Maitre CL, Hall JE, Aberdein N. Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight. Physiol Rep. 2023 Oct;11(19):10.14814/phy2.15832. doi: 10.14814/phy2.15832. PMID: 37786973; PMCID: PMC10546263.
• Zoungrana LI, Krause-Hauch M, Wang H, Fatmi MK, Li Z, Slotabec L, James AS, Didik S, Li J. Activated protein C signaling mediates neuroinflammation in seizure induced by pilocarpine. Biochem Biophys Rep. 2023 Sep 29;35:101550. doi: 10.1016/j.bbrep.2023.101550. PMID: 37823005; PMCID: PMC10562752.
• Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Dhaliwal NS, Everman S, Zafar Y, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y. Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection. medRxiv [Preprint]. 2023 Sep 15:2023.09.14.23295549. doi: 10.1101/2023.09.14.23295549. PMID: 37745424; PMCID: PMC10516085.
• Konadu B, Hosler JP, Gibert Y, Edwards KS. Analysis of oxygen consumption rates in zebrafish reveals differences based on sex, age and physical activity recovery. Front Physiol. 2023 Sep 13;14:1272366. doi: 10.3389/fphys.2023.1272366. PMID: 37781232; PMCID: PMC10534073.
• Zhang J, Wang H, Slotabec L, Cheng F, Tan Y, Li J. Alterations of SIRT1/SIRT3 subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusion. Aging Cell. 2023 Sep;22(9):e13930. doi: 10.1111/acel.13930. Epub 2023 Aug 3. PMID: 37537789; PMCID: PMC10497814.
• Ekperikpe US, Mandal S, Holt SJ, Daniels JK, Johnson TD, Cooper JS, Safir SM, Cornelius DC, Williams JM. Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2023 Sep 1;325(3):F363-F376. doi: 10.1152/ajprenal.00078.2023. Epub 2023 Jul 27. PMID: 37498548; PMCID: PMC10639024.
• Shawky, Noha M, Reckelhoff, Jane M, Alexander, Barbara T, Cardoza, Licy Yanes. Insights Into the Cardiomodulatory Effects of Sex Hormones: Implications in Transgender Care. Hypertension. 2023 Sep;80(9):1810-1820. doi 10.1161/HYPERTENSIONAHA.123.19501.
• Eddy AC, Chiang CY, Rajakumar A, Spradley FT, Dauer P, Granger JP, Rana S. Bioflavonoid luteolin prevents sFlt-1 release via HIF-1α inhibition in cultured human placenta. FASEB J. 2023 Aug;37(8):e23078. doi: 10.1096/fj.202300611R. PMID: 37405762; PMCID: PMC10348062.
• Howell JA, Gaouette N, Lopez M, Burke SP, Perkins E, Bidwell GL 3rd. Elastin-like polypeptide delivery of anti-inflammatory peptides to the brain following ischemic stroke. FASEB J. 2023 Aug;37(8):e23077. doi: 10.1096/fj.202300309RR. PMID: 37402128; PMCID: PMC10349587.
• He X, Xu R, Pan L, Bhattarai U, Liu X, Zeng H, Chen JX, Hall ME, Chen Y. Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling. Front Immunol. 2023 Jul 24;14:1215855. doi: 10.3389/fimmu.2023.1215855. PMID: 37554327; PMCID: PMC10405176.
• Poudel B, Ekperikpe US, Mandal S, Wilson GE, Shields CA, Cornelius DC, Williams JM. Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage. Am J Physiol Renal Physiol. 2023 Jul 1;325(1):F87-F98. doi: 10.1152/ajprenal.00209.2022. Epub 2023 May 11. PMID: 37167270; PMCID: PMC10292980.
• Hatano Y, VanWagner LB, Carnethon MR, Bancks MP, Carson AP, Lloyd-Jones DM, Østbye T, Viera AJ, Yano Y. Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study. Diabetologia. 2023 Jul;66(7):1235-1246. doi: 10.1007/s00125-023-05903-w. Epub 2023 Mar 21. PMID: 36941389; PMCID: PMC10286118.
• Huffman AM, Syed M, Rezq S, Anderson CD, Yanes Cardozo LL, Romero DG. Loss of microRNA-21 protects against acetaminophen-induced hepatotoxicity in mice. Arch Toxicol. 2023 Jul;97(7):1907-1925. doi: 10.1007/s00204-023-03499-z. Epub 2023 May 14. PMID: 37179516.
• Solise, Dylan, Campbell, Nathan, Ashraf, Usman, Herrock Owen, Crudup, Breland, Mallette, Jordan, Willis, Alex, Rawls, Adam Z, Turner, Ty, Cockrell, Kathy, Zheng, Baoying, Deer, Evangeline, Amaral, Lorena, Alexander Barbara T, Lamarca Babbette. Inhibition of Angiotension II Type 1-Receptor Agonistic Autoantibodies by Direct Binding Does not Impact Reduced Uterine Perfusion Pressure Offspring Birthweight and Blood Pressure at Adulthood. Am J Obstet Gynecol MFM. 2023 Jun;5(6):100945. doi:10.1016/j.ajogmf.2023.100945.
• Fang, Xing, Tang, Chengyun, Zhang, Huawei, Border, Jane J., Liu, Yedan, Shin, Seung Min, Yu, Hongwei, Roman, Richard J., Fan, Fan. Longitudinal Characterization of Cerebral Hemodynamics in the TgF344-AD Rat Model of Alzheimer's Disease. Geroscience.2023 June;45(3):1471-1490. doi:10.1007/s11357-023-00773-x.
• Han Su, Aubrey C. Cantrell, Jian-Xiong Chen, Wei Gu, and Heng Zeng. SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation. Cells. 2023 May 19;12(10):1428. doi:10.3390/cells12101428.
• Badmus OO, Kipp ZA, Bates EA, da Silva AA, Taylor LC, Martinez GJ, Lee WH, Creeden JF, Hinds TD Jr, Stec DE. The loss of hepatic PPARα in mice causes hypertension and cardiovascular disease. Am J Physiol Regul Integr Comp Physiol. 2023 May 22. doi: 10.1152/ajpregu.00057.2023. Online ahead of print.
• Speed JS, Pollock DM, Clemmer JS. Don't sweat the small stuff: skin mechanisms of sodium homeostasis and associations with long-term blood pressure.Clin Sci (Lond). 2023 May 18;137(9):769-772. doi: 10.1042/CS20230163.
• Badmus OO, Hinds TD Jr, Stec DE. Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease. Curr Hypertens Rep. 2023 May 16. doi: 10.1007/s11906-023-01242-8. Online ahead of print.
• Huffman AM, Syed M, Rezq S, Anderson CD, Yanes Cardozo LL, Romero DG.  Loss of microRNA-21 protects against acetaminophen-induced hepatotoxicity in mice. Arch Toxicol.2023 May 14. doi: 10.1007/s00204-023-03499-z. Online ahead of print.
• Zhang H, Border JJ, Fang X, Liu Y, Tang C, Gao W, Wang S, Shin SM, Guo Y, Zhang C, Gonzalez-Fernandez E, Yu H, Sun P, Roman RJ, Fan F. Enhanced Cerebral Hemodynamics and Cognitive Function Via Knockout of Dual-Specificity Protein Phosphatase 5. J Pharm Pharmacol Res. 2023;7(2):49-61. doi: 10.26502/fjppr.070. Epub 2023 May 12. PMID: 37588944; PMCID: PMC10430881.
• Mouton AJ, Aitken NM, Moak SP, do Carmo JM, da Silva AA, Omoto ACM, Li X, Wang Z, Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA, Hall JE. Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction. Front Cardiovasc Med. 2023 May 5;10:1136252. doi: 10.3389/fcvm.2023.1136252. PMID: 37215542; PMCID: PMC10196495.
• Alexander BT, South AM, August P, Bertagnolli M, Ferranti EP, Grobe JL, Jones EJ, Loria AS, Safdar B, Sequeira-Lopez MLS; American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension.2023 May;80(5):e75-e89. doi: 10.1161/HYP.0000000000000227. Epub 2023 Mar 23.
• Vitek L, Hinds TD Jr, Stec DE, Tiribelli C. The physiology of bilirubin: health and disease equilibrium. Trends Mol Med. 2023 Apr;29(4):315-328. doi: 10.1016/j.molmed.2023.01.007. Epub 2023 Feb 22.
• Mouton AJ, do Carmo JM, da Silva AA, Omoto ACM, Hall JE. Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels. Front Physiol. 2023 Apr 28;14:1139296. doi: 10.3389/fphys.2023.1139296. PMID: 37234412; PMCID: PMC10208225.
• Clemmer JS, Hillegass WB, Taylor EB. Antihypertensive effects of immunosuppressive therapy in autoimmune disease.  J Hum Hypertens.2023 Apr;37(4):300-306. doi: 10.1038/s41371-022-00682-0. Epub 2022 Apr 8.
• Clemmer JS, Ward TJ, Lirette ST. Retrospective analysis of SGLT2 inhibitors in heart failure with preserved ejection fraction. ESC Heart Fail. 2023 Apr 11. doi: 10.1002/ehf2.14347. Online ahead of print.
• Mallette JH, Crudup BF, Alexander BT. Growth Restriction in Preeclampsia: Lessons from Animal Models. CurrOpin Physiol. 2023 Apr;32:100647. doi: 10.1016/j.cophys.2023.100647. Epub 2023 Feb 13.
• Chen JX, Li L, Cantrell AC, Williams QA, Zeng H.  High Glucose Activates Prolyl Hydroxylases and Disrupts HIF-α Signaling via the P53/TIGAR Pathway in Cardiomyocyte. Cells. 2023 Mar 31;12(7):1060. doi: 10.3390/cells12071060.
• Hamid A, Yimer WK, Oshunbade AA, Kamimura D, Clark D 3rd, Fox ER, Min YI, Muntner P, Shimbo D, Pandey A, Shah AM, Mentz RJ, Jones DW, Bertoni AG, Hall JE, Correa A, Butler J, Hall ME. Impact of Diabetes and Hypertension on Left Ventricular Structure and Function: The Jackson Heart Study. J Am Heart Assoc. 2023 Mar 21;12(6):e026463. doi: 10.1161/JAHA.122.026463. Epub 2023 Mar 7.
• Fang X, Tang C, Zhang H, Border JJ, Liu Y, Shin SM, Yu H, Roman RJ, Fan F. Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease. Geroscience. 2023 Mar 18. doi: 10.1007/s11357-023-00773-x. Online ahead of print.
• Ekperikpe US, Poudel B, Shields CA, Mandal S, Cornelius DC, Williams JM. Neutralizing MIP3 α Reduces Renal Immune Cell Infiltration and Progressive Renal Injury in Young Obese Dahl Salt-Sensitive Rats. J PharmacolExp Ther. 2023 Mar;384(3):445-454. doi: 10.1124/jpet.122.001298. Epub 2022 Dec 5.PMID: 36507846.
• He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H. P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure. bioRxiv [Preprint]. 2023 Feb 9:2023.02.08.527691. doi: 10.1101/2023.02.08.527691. PMID: 36798200; PMCID: PMC9934706.
• Barnes CC, Yee KT, Vetter DE. Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss. Int J Mol Sci. 2023 Feb 7;24(4):3320. doi: 10.3390/ijms24043320.
• Kipp ZA, Martinez GJ, Bates EA, Maharramov AB, Flight RM, Moseley HNB, Morris AJ, Stec DE, Hinds TD Jr. Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content. Metabolites. 2023 Feb 1;13(2):215. doi: 10.3390/metabo13020215.
• Bates EA, Kipp ZA, Martinez GJ, Badmus OO, Soundarapandian MM, Foster D, Xu M, Creeden JF, Greer JR, Morris AJ, Stec DE, Hinds TD Jr. Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease. Biomolecules. 2023 Jan 29;13(2):252. doi: 10.3390/biom13020252.
• Flack KD, Vítek L, Fry CS, Stec DE, Hinds TD Jr. Cutting edge concepts: Does bilirubin enhance exercise performance? Front Sports Act Living. 2023 Jan 11;4:1040687. doi: 10.3389/fspor.2022.1040687. eCollection 2022.
• Martin BE, Taylor EB, Attipoe EM, Wu W, Stec DE, Showmaker KC, Garrett MR. Sex and Molecular Differences in Cardiovascular Parameters at Peak Influenza Disease in Mice. Physiol Genomics.2023 Jan 16. doi: 10.1152/physiolgenomics.00146.2022. Online ahead of print.
• Rivera-Gonzalez O, Case CT, Wilson NA, Speed JS, Taylor EB. Endothelin receptor antagonism improves glucose tolerance and adipose tissue inflammation in an experimental model of systemic lupus erythematosus.  Am J Physiol Endocrinol Metab. 2023 Jan 1;324(1):E73-E84. doi: 10.1152/ajpendo.00274.2022. Epub 2022 Dec 7.